Epitalon: doses reported in published research

Sources checked 2026-10-07 · 3 cited studies (0 human, 3 animal, 0 cell culture)

Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide studied mainly by research groups in Russia. Published dose data are from rodent studies.

No human data. No human studies of Epitalon with a stated amount were found in PubMed abstracts. (Older human reports concern Epithalamin, a pineal extract, which is a different product.)

Animal studies (3)

Animal doses are listed exactly as the studies report them. They are not converted to human amounts here; doses do not translate between species by body weight.

Animal Female C3H/He mice, from 1 year of age

Dose as reported: 0.1 µg per mouse
Route: Not stated in the abstract
Frequency / duration: 5 times a week (observation 6.5 months)

Source wording: Epitalon was injected at a dose of 0.1 microg, 5 times a week. One-year-old female C3H/He mice were kept for 6.5 months under standard conditions.

Kossoy G, Anisimov VN, Ben-Hur H et al.. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo 2006. PubMed PMID 16634527 ↗

Animal Female HER-2/neu transgenic mice, from 2 months of age

Dose as reported: 1 µg per mouse
Route: Subcutaneous
Frequency / duration: 5 consecutive days every month

Source wording: Female FVB/N HER-2/neu transgenic mice from the age of 2 months were subcutaneously injected with saline, the peptide Epitalon(R) (Ala-Glu-Asp-Gly) or with the peptide Vilon(R) (Lys-Glu) in a single dose of 1 microg/mouse for 5 consecutive days every month.

Anisimov VN, Khavinson VK, Provinciali M et al.. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer 2002. PubMed PMID 12209581 ↗

Animal Male LIO rats, 2 months old (chemically induced colon tumour model)

Dose as reported: 1 µg per rat
Route: Subcutaneous
Frequency / duration: 5 days a week

Source wording: Additionally, 5 days a week, some of the rats were given subcutaneous injections of saline at a dose of 0.1 ml during the whole experiment (group 1, control) or Epitalon at a single dose of 1 microg during the whole experiment (group 2)

Anisimov VN, Khavinson VKh, Popovich IG et al.. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett 2002. PubMed PMID 12049808 ↗

Half-life

No half-life value was found in the sources reviewed for this page.

About this page

Every figure above is copied from the cited source; the source wording is shown with each entry. Where a source does not state something, the page says so.
Only abstracts, open-access full texts, registry records and FDA labels were used, so details found only in a paywalled full text may be missing.
This page does not convert doses between species or into other measures, and gives no preparation or handling information.