Heart & blood vessels: peptides in published research

Sources checked 2026-10-07 · 10 compounds · 14 cited studies

Scope: Heart muscle, coronary and pulmonary circulation. Each entry names the model and the tissue that a published study looked at, with the citation. It describes what was studied, not what was found, and a listing here is not a claim that a compound does anything in that organ.

ARA-290 (cibinetide)
BPC-157
FOXO4-DRI
GHRP-6
Klotho (α-Klotho)
Semax
SS-31 (elamipretide)
TB-500 (thymosin beta-4)
Semaglutide
Tirzepatide

ARA-290 (cibinetide)

Animal Rats aged 18 months at the start, followed for 15 months; age-associated cardiac inflammation and structure. Published 2022 · PubMed PMID 36741836 ↗

research profile · published study amounts · sources (shop page) · lab-tested lots

Also listed under: Brain & nervous system, Kidney & urinary tract, Gut & digestive tract, Eye

BPC-157

Animal Rat monocrotaline pulmonary hypertension model; pulmonary vessels and right ventricle pressure. Published 2021 · PubMed PMID 34356886 ↗
Animal Rats given isoprenaline to induce myocardial infarction. Published 2022 · PubMed PMID 35203478 ↗

research profile · published study amounts · sources (shop page) · lab-tested lots

Also listed under: Brain & nervous system, Liver, Kidney & urinary tract, Gut & digestive tract, Skin, Muscle & tendon, Eye

FOXO4-DRI

Animal Mouse pulmonary hypertension models in which senescent cells were cleared, including with FOXO4-DRI. Published 2023 · PubMed PMID 36515093 ↗

research profile · published study amounts · sources (shop page) · lab-tested lots

Also listed under: Kidney & urinary tract, Skin, Bone & cartilage, Lungs & airways, Reproductive organs & breast

GHRP-6

Animal Rats given doxorubicin; heart structure followed by echocardiography, with histology of the heart and other organs. Published 2024 · PubMed PMID 38873418 ↗

research profile · published study amounts · sources (shop page) · lab-tested lots

Also listed under: Gut & digestive tract, Bone & cartilage, Pituitary & hormone axes

Klotho (α-Klotho)

Animal Klotho-deficient mice under cardiac stress, Klotho-overexpressing mice and mice with heart-specific TRPC6 overexpression; heart structure and TRPC6 currents in heart muscle cells (cardiomyocytes). Published 2012 · PubMed PMID 23212367 ↗
Animal Heterozygous Klotho-deficient and wild-type mice with chronic kidney disease; heart size and function by cardiac MRI, including after intravenous delivery of a transgene encoding soluble Klotho. Published 2015 · PubMed PMID 25475745 ↗
Animal Mouse acute and chronic kidney disease models given recombinant α-Klotho protein; heart imaging by MRI and heart tissue histology. Published 2017 · PubMed PMID 28131398 ↗
Cell culture & animal Klotho-overexpressing transgenic and Klotho-haploinsufficient mice with chronic kidney disease (vascular calcification), plus vascular smooth muscle cells in culture. Published 2011 · PubMed PMID 21115613 ↗

research profile · published study amounts · where it is listed (shop page) · no lab-tested lots yet

Also listed under: Brain & nervous system, Kidney & urinary tract, Muscle & tendon, Bone & cartilage, Eye, Lungs & airways

Semax

Animal Rats after myocardial infarction (coronary artery occlusion); heart rate and heart tissue at 28 days. Published 2006 · PubMed PMID 17385423 ↗

research profile · published study amounts · sources (shop page) · lab-tested lots

Also listed under: Brain & nervous system

SS-31 (elamipretide)

Animal Old and young mice; post-translational modifications of heart proteins measured by proteomics. Published 2021 · PubMed PMID 34480713 ↗

research profile · published study amounts · sources (shop page) · lab-tested lots

Also listed under: Brain & nervous system, Muscle & tendon, Eye

TB-500 (thymosin beta-4)

Animal Mice after coronary artery ligation, plus embryonic and postnatal heart muscle cells in culture. Published 2004 · PubMed PMID 15565145 ↗

research profile · published study amounts · sources (shop page) · lab-tested lots

Also listed under: Brain & nervous system, Liver, Skin, Bone & cartilage, Eye, Lungs & airways

Semaglutide

Human SELECT: randomized placebo-controlled trial in adults 45 or older with preexisting cardiovascular disease and a BMI of 27 or greater; primary end point was cardiovascular death, myocardial infarction or stroke. Published 2023 · PubMed PMID 37952131 ↗

published study amounts · lab-tested lots

Also listed under: Liver, Kidney & urinary tract, Pancreas & adipose tissue

Tirzepatide

Human SUMMIT: randomized placebo-controlled trial in 731 adults with heart failure, an ejection fraction of at least 50% and a BMI of at least 30. Published 2025 · PubMed PMID 39555826 ↗

published study amounts · lab-tested lots

Also listed under: Liver, Pancreas & adipose tissue

About this page

A compound is listed under an organ only when at least one published study or trial we could cite looked at that organ or tissue.
Sentences describe the model and tissue; they do not report results. Follow the citation for what the authors found.
Only abstracts and open-access full texts were used.